{"id":3324,"date":"2021-02-14T18:07:04","date_gmt":"2021-02-14T18:07:04","guid":{"rendered":"https:\/\/mediamalpractice.net\/?p=3324"},"modified":"2023-02-15T19:42:48","modified_gmt":"2023-02-15T19:42:48","slug":"hydroxychloroquine-is-effective-and-consistently-so-when-provided-early-for-covid-19-a-systematic-review","status":"publish","type":"post","link":"https:\/\/mediamalpractice.net\/?p=3324","title":{"rendered":"Hydroxychloroquine is effective, and consistently so when provided early, for COVID-19: a systematic review"},"content":{"rendered":"\n<p>TWITTER:<\/p>\n<div class=\"\" data-block=\"true\" data-editor=\"d31o4\" data-offset-key=\"e9jge-0-0\">\n<div class=\"public-DraftStyleDefault-block public-DraftStyleDefault-ltr\" data-offset-key=\"e9jge-0-0\"><span data-offset-key=\"e9jge-0-0\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33042552\/<\/span><\/div>\n<\/div>\n<div class=\"\" data-block=\"true\" data-editor=\"d31o4\" data-offset-key=\"8nssu-0-0\">\n<div class=\"public-DraftStyleDefault-block public-DraftStyleDefault-ltr\" data-offset-key=\"8nssu-0-0\"><span data-offset-key=\"8nssu-0-0\">Hydroxychloroquine is effective, consistently so when provided early, for COVID-19: (HCQ) has shown efficacy against COVID-19 in some but not all studies. systematic review shows HCQ to be effective against COVID-19,more so when provided early<\/span><\/div>\n<div data-offset-key=\"8nssu-0-0\">\u00a0<\/div>\n<\/div>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33042552\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33042552\/<\/a><\/p>\n<header id=\"heading\" class=\"heading\">\n<div id=\"full-view-heading\" class=\"full-view\">\n<div class=\"article-citation\">\n<div class=\"article-source\"><span class=\"period\">\u00a0<\/span><span class=\"cit\">2020 Nov;38:100776.<\/span><\/div>\n\u00a0<span class=\"citation-doi\">doi: 10.1016\/j.nmni.2020.100776.<\/span>\u00a0<span class=\"secondary-date\">Epub 2020 Oct 5.<\/span><\/div>\n<h1 class=\"heading-title\">Hydroxychloroquine is effective, and consistently so when provided early, for COVID-19: a systematic review<\/h1>\n<div class=\"inline-authors\">\n<div class=\"authors\">\n<div class=\"authors-list\"><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Prodromos+C&amp;cauthor_id=33042552\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"C Prodromos\">C Prodromos<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33042552\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Rumschlag+T&amp;cauthor_id=33042552\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"T Rumschlag\">T Rumschlag<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33042552\/#affiliation-2\">2<\/a><\/sup><\/span><\/div>\n<\/div>\n<\/div>\n<div class=\"short-article-details\">Affiliations\u00a0<button id=\"toggle-authors\" class=\"more-details\" data-alt-text=\"Collapse\" aria-controls=\"expanded-authors\" aria-expanded=\"false\" data-pinger-ignore=\"\">expand<\/button><\/div>\n<ul id=\"full-view-identifiers\" class=\"identifiers\">\n<li><span class=\"identifier pubmed\"><span class=\"id-label\">PMID:\u00a0<\/span><strong class=\"current-id\" title=\"PubMed ID\">33042552<\/strong><\/span><\/li>\n\u00a0\n<li><span class=\"identifier pmc\"><span class=\"id-label\">PMCID:\u00a0<\/span><a class=\"id-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc7534595\/\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"full_text\" data-ga-action=\"PMCID\">PMC7534595<\/a><\/span><\/li>\n\u00a0\n<li><span class=\"identifier doi\"><span class=\"id-label\">DOI:\u00a0<\/span><a class=\"id-link\" href=\"https:\/\/doi.org\/10.1016\/j.nmni.2020.100776\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"full_text\" data-ga-action=\"DOI\">10.1016\/j.nmni.2020.100776<\/a><\/span><\/li>\n<\/ul>\n<span class=\"free-label\">Free PMC article<\/span><\/div>\n<\/header>\n<div id=\"abstract\" class=\"abstract\">\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p>Hydroxychloroquine (HCQ) has shown efficacy against coronavirus disease 2019 (COVID-19) in some but not all studies. We hypothesized that a systematic review would show HCQ to be effective against COVID-19, more effective when provided earlier, not associated with worsening disease and safe. We searched PubMed, Cochrane, Embase, Google Scholar and Google for all reports on HCQ as a treatment for COVID-19 patients. This included preprints and preliminary reports on larger COVID-19 studies. We examined the studies for efficacy, time of administration and safety. HCQ was found to be consistently effective against COVID-19 when provided early in the outpatient setting. It was also found to be overall effective in inpatient studies. No unbiased study found worse outcomes with HCQ use. No mortality or serious safety adverse events were found. HCQ is consistently effective against COVID-19 when provided early in the outpatient setting, it is overall effective against COVID-19, it has not produced worsening of disease and it is safe.<\/p>\n<\/div>\n<p><strong class=\"sub-title\">Keywords:\u00a0<\/strong>Azithromycin; COVID-19; SARS-CoV-2; hydroxychloroquine; outpatient.<\/p>\n<\/div>\n<p id=\"copyright\" class=\"copyright\">\u00a9 2020 The Authors.<\/p>\n<div id=\"similar\" class=\"similar-articles\">\n<h2 class=\"title\">Similar articles<\/h2>\n<ul id=\"similar-articles-list\" class=\"articles-list\">\n<li class=\"full-docsum\">\n<div class=\"docsum-content\"><a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32297988\/\" data-ga-category=\"similar_article\" data-ga-action=\"32297988\" data-ga-label=\"\">Virological and clinical cure in COVID-19 patients treated with hydroxychloroquine: A systematic review and meta-analysis.<\/a>\n<div class=\"docsum-citation full-citation\"><span class=\"docsum-authors full-authors\">Sarma P, Kaur H, Kumar H, Mahendru D, Avti P, Bhattacharyya A, Prajapat M, Shekhar N, Kumar S, Singh R, Singh A, Dhibar DP, Prakash A, Medhi B.<\/span><span class=\"docsum-journal-citation full-journal-citation\">J Med Virol. 2020 Jul;92(7):776-785. doi: 10.1002\/jmv.25898. 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Available at:<\/li>\n<\/ol>\n<\/li>\n<li>\n<ol class=\"references-and-notes-list\">\n<li class=\"skip-numbering\" value=\"1\">Lupkin S. NPR; 29 June 2020. Remdesivir priced at more than $3,100 for a course of treatment.<a title=\"External link: https:\/\/www.npr.org\/sections\/health-shots\/2020\/06\/29\/884648842\/remdesivir-priced-at-more-than-3-100-for-a-course-of-treatment\" href=\"https:\/\/www.npr.org\/sections\/health-shots\/2020\/06\/29\/884648842\/remdesivir-priced-at-more-than-3-100-for-a-course-of-treatment\" target=\"_blank\" rel=\"noopener nofollow\">https:\/\/www.npr.org\/sections\/health-shots\/2020\/06\/29\/884648842\/remdesivir-priced-at-more-than-3-100-for-a-course-of-treatment<\/a>\u00a0Available at:<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>TWITTER: https:\/\/pubmed.ncbi.nlm.nih.gov\/33042552\/ Hydroxychloroquine is effective, consistently so when provided early, for COVID-19: (HCQ) has shown efficacy against COVID-19 in some but not all studies. systematic review shows HCQ to be effective against COVID-19,more so when provided early \u00a0 https:\/\/pubmed.ncbi.nlm.nih.gov\/33042552\/ \u00a02020 Nov;38:100776. \u00a0doi: 10.1016\/j.nmni.2020.100776.\u00a0Epub 2020 Oct 5. Hydroxychloroquine is effective, and<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/mediamalpractice.net\/index.php?rest_route=\/wp\/v2\/posts\/3324"}],"collection":[{"href":"https:\/\/mediamalpractice.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mediamalpractice.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mediamalpractice.net\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/mediamalpractice.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3324"}],"version-history":[{"count":2,"href":"https:\/\/mediamalpractice.net\/index.php?rest_route=\/wp\/v2\/posts\/3324\/revisions"}],"predecessor-version":[{"id":3613,"href":"https:\/\/mediamalpractice.net\/index.php?rest_route=\/wp\/v2\/posts\/3324\/revisions\/3613"}],"wp:attachment":[{"href":"https:\/\/mediamalpractice.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3324"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mediamalpractice.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3324"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mediamalpractice.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}